Effect of Polymer Type, Concentration and Formulation Technique on Mucoadhesive Strength and Swelling Index of Clarithromycin Tablets

Abstract

This study aims to evaluate the effect of polymer type, concentration, and formulation technique on mucoadhesion and the Swelling Index of matrix tablets. Tablets were formulated by wet-granulation, solid dispersions, and direct compression techniques using different polymers in different concentrations (D:P 5:1, 5:2, and 5:3). Swelling Index and Mucoadhesive strength were analyzed for all the formulations (F1-15). The physicochemical parameters of the tablets were found to be within the acceptable limit. The swelling index for matrix tablets (F1-15) prepared by wet-granulations technique was found to be ranging from 33.81±2.42 - 67.36±0.77; by solid dispersions technique ranging from 34.02±1.32 - 65.09±1.08; by direct compression technique ranging from 36.82±2.02 - 68.35±1.73, after 6 hours. Mucoadhesive strength ranged from 13.673 ± 1.542 to 40.378 ± 2.345N, increasing with an increase in the polymer concentrations. The study helped to find the drug's optimum formulation with excellent bio-adhesive strength.